Myogenic differentiation of human mesenchymal stem cells

Details Myogenic differentiation of human mesenchymal stem cells Myogenic differentiation of human mesenchymal stem cells

A - Human Necessities

61

K

A61K 35/28 (2006.01) A61K 35/34 (2006.01) A61K 35/12 (2006.01) C12N 5/08 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2223594

Compositions of matter are provided which comprise a mixture of isolated muscle precursor cells with either isolated mesenchymal stem cells or isolated periosteum cells, optionally further including a myoinductive agent. Also provided are a method for inducing isolated human mesenchymal stem cells to differentiate into myogenic cells, a method for producing dystrophin-positive myogenic cells in a mammal with commitment muscle regeneration, and a use of the compositions for treating muscular dystrophy.

L'invention porte sur des compositions comprenant un mélange de cellules musculaires précurseurs isolées et de cellules souches isolées mésenchymateuses ou du périoste, comportant en outre, éventuellement, un agent myoinducteur. L'invention porte également sur un procédé amenant des cellules souches mésenchymateuses humaines à se différencier en souches myogènes, sur un procédé de production chez les mammifères de cellules myogènes, sur un procédé de production chez les mammifères de cellules myogènes dystrophine-positives, sur un procédé de régénération musculaire, et sur un procédé de traitement des dystrophies musculaires.

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