Myostatin binding proteins

Details Myostatin binding proteins Myostatin binding proteins

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61P 21/00 (2006.01)

Patent

CA 2747062

Description of antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. Furthermore, description of the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.

L'invention porte sur des protéines de liaison à un antigène, telles que des anticorps, qui se lient à la myostatine, sur des polynucléotides codant pour de telles protéines de liaison à un antigène, sur des compositions pharmaceutiques comprenant lesdites protéines de liaison à un antigène et sur des procédés de fabrication. En outre, l'invention porte sur l'utilisation de telles protéines de liaison à un antigène dans le traitement ou la prophylaxie de maladies associées à une diminution quelconque parmi une diminution de la masse musculaire, une diminution de la force musculaire et une diminution de la fonction musculaire ou une association de celles-ci.

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