Myotilin, an actin-organizing protein

Details Myotilin, an actin-organizing protein Myotilin, an actin-organizing protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2333469

The present invention concerns a novel cytoskeletal protein, myotilin, which contains Ig-like domains homologous to a giant sarcomeric structural protein titin. Myotilin is expressed in skeletal and cardiac muscles, it colocalizes with .alpha.-actinin in the sarcomeric I-bands and directly interacts with .alpha.-actinin. Expression of myotilin in mammalian non-muscle cells and in yeast causes reorganization of actin into thick F-actin bundles and inhibits growth of yeast cells.

L'invention concerne une nouvelle protéine cytosquelettique, la myotiline, contenant des domaines de type Ig homologues avec une titine structurale sarcomérique géante. La myotiline est exprimée dans les muscles squelettiques et cardiaques, elle se trouve avec l' alpha -actinine dans les bandes I sarcomériques et interagit directement avec l' alpha -actinine. L'expression de la myotiline dans les cellules non musculaires chez les mammifères et dans la levure entraîne la réorganisation d'actine en faisceaux d'actine F épais et présentant une croissance de cellules de levure.

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