N-1-azabicyclo¬2,2,2|-oct-3yl)-benzamide compounds

Details N-1-azabicyclo¬2,2,2|-oct-3yl)-benzamide compounds N-1-azabicyclo¬2,2,2|-oct-3yl)-benzamide compounds

C - Chemistry, Metallurgy

07

D

167/231, 260/272

C07D 453/02 (2006.01) A61K 31/445 (2006.01) C07C 237/44 (2006.01)

Patent

CA 1303616

Abstract Novel substituted benzamides of the formula Image XXI wherein R1, R2, R3, R4, R5 and A are as defined herein are useful in the treatment of emesis, and particularly chemotherapy-induced emesis in cancer patients. Some of the compounds are also useful in disorders relating to impaired gastric motility.

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