N-(1-substituted-4,5-dihydro-1h-pyrazol-4-yl) benzamides

Details N-(1-substituted-4,5-dihydro-1h-pyrazol-4-yl) benzamides N-(1-substituted-4,5-dihydro-1h-pyrazol-4-yl) benzamides

C - Chemistry, Metallurgy

07

D

167/238, 260/315

C07D 231/06 (2006.01) A61K 31/415 (2006.01)

Patent

CA 1244450

ABSTRACT OF THE INVENTION N-(1-SUBSTITUTED-4,5-DIHYDRO-1H- PYRAZOL-4-YL)BENZAMIDES Novel N-(1-Substituted-4,5-dihydro-1H-pyrazol-4-yl) benzamides having the general formula: Image wherein R is loweralkyl, cycloalkyl or phenylloweralkyl and R1 is selected from hydroxy, cyano, nitro, amino, methylamino, dimethylamino, halo, trifluoromethyl, lower- alkyl, loweralkoxy, sulfamoyl or acetamido, and when n is more than 1 up to 3, R1 can be the same or different, are disclosed as having gastrokinetic and anti-emetic utility in animals and pharmaceutical compositions therefor. A process for preparing the compounds by oxidation of 1,2- disubstituted-N-(4-pyrazolidinyl)benzamides with a metal hypochlorite is disclosed.

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