C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/437 (2006.01) A61P 1/00 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07D 209/04 (2006.01) C07D 231/10 (2006.01) C07D 231/56 (2006.01) C07D 233/54 (2006.01) C07D 249/06 (2006.01) C07D 249/18 (2006.01) C07D 401/04 (2006.01) C07D 473/00 (2006.01)
Patent
CA 2691031
Compounds are provided that act as potent antagonists of the CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
Cette invention concerne des composés qui agissent comme de puissants antagonistes du récepteur CCR9. Les études précliniques démontrent que ces composés sont utiles pour traiter l'inflammation, caractéristique du CCR9. Ces composés sont généralement des dérivés arylsulfonamides et sont utilisés dans les compositions pharmaceutiques, dans les procédés de traitement des maladies associées au CCR9 et en tant que témoins dans les dosages d'identification des antagonistes du CCR9.
Charvat Trevor T.
Hu Cheng
Melikian Anita
Novack Aaron
Pennell Andrew M.k.
Cassan Maclean
Chemocentryx Inc.
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