N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-car...

Details N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-car... N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-car...

C - Chemistry, Metallurgy

07

D

C07D 213/89 (2006.01) A61K 31/44 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2360451

The invention relates to N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1- oxide-3-carboximidoyl chloride, its stereoisomers and the acid addition salts thereof, pharmaceutical compositions containing the same, the use of these compounds in the treatment of pathological insulin resistance, and for the treatment of pathological conditions associated therewith, for the treatment of pathological insulin resistance, and the treatment of pathological conditions associated therewith, by simultaneous treatment and prevention of diabetes-induced chronic complications, especially retinopathy, neuropathy and nephropathy and/or with simultaneous increasing pathologically decreased peripheral neuroregeneration caused by diabetes and methods of treatment.

L'invention porte sur du chlorure de N-[2-hydroxy-3-(1-pipéridinyl)-propoxyl]-pyridine-1-oxyde-3-carboximidoyl, ses stéréoisomères et ses sels acidifiants, sur des compositions pharmaceutiques le contenant, sur l'utilisation de ces composés dans le traitement de la résistance pathologique à l'insuline et des états pathologiques liés, dans le traitement de la résistance pathologique à l'insuline et des états pathologiques liés, sur le traitement et la prévention simultanés de complications chroniques liées au diabète, et en particulier de rétinopathies, de neuropathies, et de néphropathies, et/ou l'accroissement simultané de la neurorégénération périphérique ayant pathologiquement chuté en raison du diabète, et sur les procédés de traitement associées.

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