N-(2-pyrrolidinyl alkyl) substitutes and derivatives thereof

Details N-(2-pyrrolidinyl alkyl) substitutes and derivatives thereof N-(2-pyrrolidinyl alkyl) substitutes and derivatives thereof

C - Chemistry, Metallurgy

07

D

260/323

C07D 207/09 (2006.01) C07D 207/08 (2006.01)

Patent

CA 1047504

A B S T R A C T The invention relates to novel N-(2-pyrrolidinyl- alkyl)benzamides of the formula: Image in which A represents a hydrogen atom, a C1-5 alkyl group or a C2-5 alkenyl group; X represents a hydrogen atom, a C1-5 alkoxy group, a C1-5 alkyl group, a C2-5 alkenyloxy group or a C2-5 alkenyl group; Y represents a hydrogen atom, a halogen atom, a C1-5 alkyl, C1-5 alkoxy, amino, or amino substituted group, such as alkylamino, acylamino, benzylamino, or a alkoxy- carbonylamino; Z represents a hydrogen atom, a halogen atom, a C1-5 alkoxy group, a C1-5 alkylsulfonyl group, or a SO2NR1R2 group in which R1 and R2 which can be identical or different are hydrogen or a C1-5 lower alkyl group, or together with the nitrogen atom to which they are attached form a heterocycle, possibly containing another heteroatom; W represents an alkylene group having from 1 to 4 carbon atoms which can form a straight or branched chain, and m represents an integer of 1, 2 or 3. The products are useful anti-emetics, anti-ulcer agents and are useful for modifying the central nervous system.

221240

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