N-(2-substituted alkyl)-n'-[(imidazole-4-yl) alkyl] guanidine

Details N-(2-substituted alkyl)-n'-[(imidazole-4-yl) alkyl] guanidine N-(2-substituted alkyl)-n'-[(imidazole-4-yl) alkyl] guanidine

C - Chemistry, Metallurgy

07

D

260/200, 167/208

C07D 233/64 (2006.01) C07D 233/54 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1296716

21027-326 A B S T R A C T The invention relates to N-(2-substituted alkyl)-N'- [imidazole-4-yl)alkyl] guanidines having the formula 1, Image 1 wherein m is 1, 2 or 3; n is 2 or 3; X is a) S, O or CH2, and Y is a R-substituted diphenylmethyl group or (10,11-dihydro) 5H- dibenzo-[a-d]-aycloheptene-5-yl group, or is b) Image , wherein Y1 is a R-substituted phenyl group and Y is also a R-substituted phenyl group in that Y and Y1 need not be substituted simultaneously or Y is a R-substituted benzyl group, or is c) =CH-, and Y is a R-substituted diphenylmethylidenyl group or (10,11-dihydro)-5H-dibenzo-[a,d]-cycloheptene-5-ylidene group, R is H, alkyl, alkoxy, halogen and/or trihalogen methyl, with the understanding that from all the appropriate phenyl rings one or more may be substituted by a R-substitutad heterocyclic aromatic ring and their addition salts, with activity against heart failure and allergic conditions.

540131

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