C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/519 (2006.01) A61P 9/10 (2006.01) A61P 25/06 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 487/14 (2006.01)
Patent
CA 2601766
The present invention relates to compounds that are useful to inhibit, regulate and/or modulate tyrosine and serine/threonine kinase and kinase-like proteins, such as RAF kinase, a serine/threonine kinase that functions in the MAP kinase signaling pathway. The application is also concerned with compositions which contain these compounds, and methods of using them to treat tyrosine and serine/threonine kinase and kinase-like dependent diseases, such as angiogenesis, cancer and cardiac hypertrophy, and with other subject matter.
L'invention concerne des composés utilisés pour inhiber, réguler et/ou moduler la tyrosine et la sérine/thréonine kinase et des protéines de type kinase, telles que la RAF kinase, une sérine/thréonine kinase qui fonctionne dans le passage de signalisation de la MAP kinase. L'application concerne également des compositions contenant lesdits composés, et des procédés d'utilisation des compositions, permettant de traiter les maladies engendrées par la tyrosine et la sérine/ thréonine kinase et du type de kinase, telles que l'angiogenèse, le cancer, l'hypertrophie cardiaque, et dans d'autres applications.
Perez Lawrence Blas
Sheng Tao
Fetherstonhaugh & Co.
Novartis Ag
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