N-(3-amino-2-hydroxy-propyl) substituted alkylamide compounds

Details N-(3-amino-2-hydroxy-propyl) substituted alkylamide compounds N-(3-amino-2-hydroxy-propyl) substituted alkylamide compounds

C - Chemistry, Metallurgy

07

C

C07C 233/35 (2006.01) A61K 31/164 (2006.01) A61P 25/28 (2006.01) C07C 233/40 (2006.01) C07C 235/20 (2006.01) C07C 235/34 (2006.01) C07C 271/22 (2006.01) C07C 311/06 (2006.01) C07C 323/62 (2006.01) C07D 207/26 (2006.01) C07D 207/327 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/18 (2006.01) C07D 209/30 (2006.01) C07D 209/48 (2006.01) C07D 211/76 (2006.01) C07D 213/38 (2006.01) C07D 213/56 (2006.01) C07D 213/64 (2006.01) C07D 213/74 (2006.01) C07D 231/12 (2006.01) C07D 233/54 (2006.01) C07D 2

Patent

CA 2453503

Disclosed are compounds of the formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzeheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

L'invention concerne des composés de formule (I), utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies similaires. Les composés selon l'invention comprennent des inhibiteurs de l'enzyme bêta-sécrétase, utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies se caractérisant par le dépôt du peptide A bêta, chez un mammifère. Les composés selon l'invention peuvent être utilisés dans des compositions pharmaceutiques et des méthodes thérapeutiques visant à réduire la formation du peptide A bêta.

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