N-¬3-dimethylamino-2-(4-pyridinyl)-2-...

Details N-¬3-dimethylamino-2-(4-pyridinyl)-2-... N-¬3-dimethylamino-2-(4-pyridinyl)-2-...

C - Chemistry, Metallurgy

07

D

260/296

C07D 213/22 (2006.01) C07D 213/38 (2006.01) C07D 213/53 (2006.01) C07D 213/82 (2006.01) C07D 213/85 (2006.01)

Patent

CA 1128523

ABSTRACT OF THE DISCLOSURE Amrinone intermediates are prepared by reacting 4-picoline with at least three mole equivalents of phosgene per mole of 4-picoline and excess dimethylformamide to produce N-[3-dimethylamino-2-(4-pyridinyl)-2-propenyl idene]-N-methylmethaniminium chloride hydrochloride, then reacting the latter with Q-CH2CONH2 and at least three mole equivalents of base in anhydrous medium and then neutralizing the reaction mixture to produce 5-Q-[3,4'- bipyridin]-6(1H)-one, where Q is cyano or carbamyl. Other aspects of the invention are the separate steps of preparing said iminium salt and then con- verting it to said 5-Q-[3,4'bipyridin]-6(1H)-one, and also cardiotonic com- position and method for increasing cardiac contractility using said iminium salt or pharmaceutically-acceptable acid-addition salt thereof as the active cardiotonic.

371690

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