C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/218, 260/255
C07F 9/6561 (2006.01) A61K 31/675 (2006.01) C07F 9/547 (2006.01) C07F 9/6512 (2006.01)
Patent
CA 2040982
N-(3-Fluoro-2-phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases method of producing them and their use as active principles of drugs, The invention relates to suppression of multi- plication of viruses, particularly retroviruses, by application of the new compounds, N-(3-fluoro-2- -phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases. These compounds are obtained by the reaction of the N-(3-fluoro-2- -hydroxypropyl) derivatives of purine and pyrimidine heterocyclic bases with diesters of p-toluenesulfonyl- oxymethylphosphonic acid in the presence of sodium hydride.
Balzarini Jan
de Clercq Erik
Holy Antonin
Jindrich Jindrich
Ceskoslovenska Akademie Ved
Institute Of Organic Chemistry And Biochemistry Academy Of Scien
Katholieke Universiteit Rega
Robic
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