N- ((3-oxo2, 3-dihydro-1h-isoindol-1-yl) acetyl) guanidine...

Details N- ((3-oxo2, 3-dihydro-1h-isoindol-1-yl) acetyl) guanidine... N- ((3-oxo2, 3-dihydro-1h-isoindol-1-yl) acetyl) guanidine...

C - Chemistry, Metallurgy

07

D

C07D 209/46 (2006.01) A61K 31/4035 (2006.01)

Patent

CA 2488373

Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them. The present invention relates to the novel isoindolone derivatives of the Formula (I), in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.

L'invention concerne des dérivés d'isoindolone, un procédé de réalisation et des intermédiaires de ce procédé, l'utilisation de ces dérivés comme médicaments et des préparations pharmaceutiques les contenant. Cette invention concerne donc de nouveaux dérivés d'isoindolone de formule (I), dans laquelle R1 à R6 ont les significations indiquées dans les revendications. Les composés de la présente invention sont utiles en tant que médicaments antiarhythmiques, comportant un composant cardioprotecteur pour la prophylaxie et le traitement de l'infarctus et pour le traitement de l'angine pectorale. Ces composés inhibent de manière préventive les processus pathophysiologiques associés au développement de dégradations dues à l'ischémie, notamment le déclenchement d'arythmies cardiaques dues à l'ischémie et d'insuffisance cardiaque.

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