N-[4-[(3-aminopropyl)amino]butyl]-2,2 dihydroxyethanamide...

Details N-[4-[(3-aminopropyl)amino]butyl]-2,2 dihydroxyethanamide... N-[4-[(3-aminopropyl)amino]butyl]-2,2 dihydroxyethanamide...

C - Chemistry, Metallurgy

07

C

260/556.2

C07C 235/10 (2006.01)

Patent

CA 1183873

-1- N-[4-[(3-AMINOPROPYL)AMINO]BUTYL]- 2,2-DIHYDROXYETHANAMIDE AND SYNTHESIS THEREOF Abstract of the Disclosure N-[4-[(3-Aminopropyl)amino]butyl]-2,2-dihydroxy- ethanamide is an immunostimulant in animals and an intermediate for synthesis of the antibiotic BMG162-aF2 Summary of the Invention This invention relates to N-[4-[(3-aminopropyl)amino]- butyl]-2,2-dihydroxyethanamide of the formula (I) Image I and acid addition salts thereof and to a process for their synthesis. Background of the Invention Umezawa et al. in U.S. Patent No. 4,416,899 filed August 28, 1981 described the new antibiotic BMG162-aF2, its production by fermentation and isolation thereof from fermentation broths. The present inventors in U.S. Patent No. 4,430,346 (Japanese Application No. 69340/81 filed May 11, 1981 describe a method for the synthesis of a new stereo- isomer of BMG162-aF2 referred to therein as GHA-GS, and the

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