N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl) -n-phenylamines...

Details N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl) -n-phenylamines... N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl) -n-phenylamines...

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2460909

The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders such as cancer, leukaemia, psoriasis and the like.

Cette invention a trait à des 4-hétéroaryl-pyrimidines substituées en position 2, à leur préparation, à des compositions pharmaceutiques les contenant ainsi qu'à leur utilisation comme inhibiteur de kinases dépendant de la cycline et, partant, à leur utilisation dans le traitement de troubles de prolifération cellulaire, notamment des cancers, de la leucémie, du psoriasis et analogue.

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