N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use

Details N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use

C - Chemistry, Metallurgy

07

D

C07D 277/52 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/44 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2210613

The invention is concerned with the use of sulphonamide derivatives of the general formula (see fig. I) wherein R Signifies lower-alkyl, phenyl, benzyl, naphthyl, pyridyl or thienyl, optionally substituted by one or more lower-alkyl, lower-alkoxy, lower-alkyl carbonyl-amino, halogen, cycloalkyl, nitro, amino, methylenedioxy, phenoxy or benzyloxy substituents, and the aromatic rings, can, in turn, be substituted by nitro, halogen or amino, R1-R4 signify hydrogen, halogen, hydroxy, lower-alkyl, nitro, cyano, amino, lower-alkoxy, benzyloxy, trifluoromethyl or phenyl, optionally substituted by one or more lower-alkyl, trifluoromethyl, nitro, amino or hydroxy substituents, and wherein R1 and R2 or R2 and R3 together can form a benzene ring which optionally can be substituted by halogen, trifluromethyl, nitro, lower-alkyl or lower alkoxy, and of their pharmaceutically acceptable salts as kynurenin-3-hydroxylase inhibitors in the control or prevention of neuro-degenerative disorders, neurological disorders resulting from an activation of the immune system, or psychiatric illnesses and, respectively, for the production of corresponding medicaments.

L'invention concerne l'utilisation de dérivés de sulfonamide de formule générale (voir fig. I) où R est un groupe alkyle inférieur, phényle, benzyle, naphtyle, pyridyle ou thiényle, facultativement substitué par un ou plusieurs substituants alkyle inférieur, alcoxy inférieur, alkyle inférieur carbonyl-amino, halogène, cycloalkyle, nitro, amino, méthylènedioxy, phénoxy ou benzyloxy et les noyaux aromatiques peuvent, à leur tour, être substitués par un groupe nitro, halogène ou amino, R1-R4 correspondent à un hydrogène, un halogène, un hydroxy, un alkyle inférieur, un nitro, un cyano, un amino, un alcoxy inférieur, un benzyloxy, un trifluorométhyle ou un phényle, facultativement substitué par un ou plusieurs substituants alkyle inférieur, trifluorométhyle, nitro, amino ou hydroxy et où R1 et R2 ou R2 et R3 ensemble peuvent former un noyau benzénique qui, facultativement, peut être substitué par un halogène, un triflurométhyle, un nitro, un alkyle inférieur ou un alcoxy inférieur; l'invention concerne également l'utilisation de leurs sels pharmaceutiquement acceptables comme inhibiteurs de la kynurénine-3-hydroxylase pour le traitement ou la prévention des affections neurodégénératives, des troubles neurologiques résultant d'une activation du système immunitaire ou des troubles psychiatriques ainsi que la production des médicaments correspondants.

Affiliated with

Also associated with

Rating

N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1748825