N-(4-carbamimidoyl-benzyl) -2-alkoxy-2-heterocyclyl...

Details N-(4-carbamimidoyl-benzyl) -2-alkoxy-2-heterocyclyl... N-(4-carbamimidoyl-benzyl) -2-alkoxy-2-heterocyclyl...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61P 7/02 (2006.01) C07D 209/48 (2006.01) C07D 213/74 (2006.01) C07D 213/76 (2006.01) C07D 231/12 (2006.01) C07D 235/16 (2006.01) C07D 249/08 (2006.01) C07D 263/32 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2549825

The invention is concerned with novel heterocyclyl substituted mandelic acid derivatives of formula (I) wherein R1 to R6 and A are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.

L'invention concerne de nouveaux dérivés d'acide mandélique substitués par des hétérocyclyles, qui ont la formule (I) dans laquelle R?1¿ à R?6¿ et A sont définis dans la description et les revendications, ainsi que leurs sels physiologiquement acceptables. Ces composés inhibent la formation de facteurs de coagulation Xa, IXa et de thrombine, provoquée par le VIIa et le facteur de tissus, et peuvent s'utiliser en tant que médicaments.

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