N-[4-(heteroarylmethyl)phenyl]-heteroarylamines

Details N-[4-(heteroarylmethyl)phenyl]-heteroarylamines N-[4-(heteroarylmethyl)phenyl]-heteroarylamines

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/41 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 473/34 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2258165

The present invention is concerned with compounds of formula (I), the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-6alkyl or aryl; R2 is hydrogen; optionally substituted C1-12alkyl; C3-7cycloalkyl; C2-8alkenyl, optionally substituted pyrrolidinyl or aryl; R3 is hydrogen, optionally substituted C1-6alkyl or aryl; Het is an optionally substituted unsaturated heterocycle selected from imidazolyl, triazolyl, tetrazolyl and pyridinyl; formula (1) is an optionally substituted un-saturated mono- or bicyclic heterocycle; and aryl is optionally substituted phenyl. The present invention also relates to processes for their preparation and compositions comprising said new compounds, as well as their use as a medicine.

L'invention concerne les composés présentant la formule (I), les N-oxydes, les sels additifs pharmaceutiquement acceptables et les formes stéréochimiquement isomères de ces composés. Dans la formule, R<1> représente hydrogène, hydroxy, alkyle C1-6 ou aryle; R<2> représente hydrogène, alkyle C1-12 éventuellement substitué, cycloalkyle C3-7; alcényle C2-8, pyrrolidinyle éventuellement substitué ou aryle; R<3> représente hydrogène, alkyle C1-6 éventuellement substitué ou aryle. Het représente un hétérocycle non saturé éventuellement substitué sélectionné parmi l'imidazolyle, triazolyle, tétrazolyle et pyridinyle; la formule (1) est un hétéroxycle mono- ou bicyclique non saturé éventuellement substitué et aryle est phényle éventuellement substitué. L'invention concerne des procédés pour la préparation de ces composés et des compositions les comprenant ainsi que leur utilisation comme médicaments.

Affiliated with

Also associated with

Rating

N-[4-(heteroarylmethyl)phenyl]-heteroarylamines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-[4-(heteroarylmethyl)phenyl]-heteroarylamines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-[4-(heteroarylmethyl)phenyl]-heteroarylamines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1486736