C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61K 31/454 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2394552
The present invention describes compounds of formula (I): and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The formula (I) compounds are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimer's disease, chemotherapy- induced alopecia, and cardiovascular disease.
La présente invention concerne des composés de formule (I) et des énantiomères, des diastéréomères et des sels correspondants acceptables sur le plan pharmaceutique. Les composés de la formule (I) sont des inhibiteurs de la protéine kinase et sont utilisés dans le traitement de maladies prolifératives, par exemple, le cancer, les inflammations et l'arthrite. On peut également les utiliser pour traiter la maladie d'Alzheimer, l'alopécie induite par chimiothérapie ou les maladies cardiovasculaires.
Misra Raj N.
Xiao Hai-Yun
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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