N-5,6,7,8-tetrahydro(1,6)naphthyridine-n'-phenylurea...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2303994

N-(naphthyridinyl)-N'-phenyl-ureas/thioureas of general formula (I) are useful for the treatment and/or prophylaxis of anxiety, mania, depression, panic disorders and/or aggression, disorders associated with a subarachnoid haemorrhage or neural shock, the effects associated with withdrawal from substances of abuse such as cocaine, nicotine, alcohol and benzodiazepines, disorders treatable and/or preventable with anti-convulsive agents, such as epilepsy including post-traumatic epilepsy, Parkinson's disease, psychosis, migraine, cerebral ischaemia, Alzheimer's disease and other degenerative diseases such as Huntingdon's chorea, schizophrenia, obsessive compulsive disorders (OCD), neurological deficits associated with AIDS, sleep disorders (including circadian rhythm disorders, insomnia and narcolepsy), tics (e.g. Giles de la Tourette's syndrome), traumatic brain injury, tinnitus, neuralgia, especially trigeminal neuralgia, neuropathic pain, dental pain, cancer pain, inappropriate neuronal activity resulting in neurodysthesias in diseases such as diabetes, multiple sclerosis (MS) and motor neurone disease, ataxias, muscular rigidity (spasticity), temporomandibular joint dysfunction, and amyotrophic lateral sclerosis (ALS).

N-(naphtyridinyl)-N'-phénylurées/thiourées de formule générale (I) qui sont utiles pour traiter et/ou prévenir l'anxiété, la manie, la dépression, la panique et/ou l'agression, les troubles associés à une hémorragie sous-arachnoïdienne ou au choc nerveux, les effets associés au sevrage de substances entraînant une dépendance telles que la cocaïne, la nicotine, l'alcool et les benzodiazépines, les troubles pouvant être traités et/ou prévenus à l'aide d'agents anti-convulsifs tels que l'épilepsie, y compris l'épilepsie post-traumatique, la maladie de Parkinson, la psychose, la migraine, l'ischémie cérébrale, la maladie d'Alzheimer et d'autres maladies dégénératives telles que la chorée de Huntington, la schizophrénie, les troubles obsessifs impulsifs, les déficiences neurologiques associées au SIDA, les troubles du sommeil (y compris les troubles du rythme circadien, l'insomnie et la narcolepsie), les tics ( par ex. la maladie de Tourette), les lésions cérébrales traumatiques, l'acouphène, la névralgie, en particulier la névralgie faciale, les douleurs neuropathiques, les douleurs dentaires, les douleurs du cancer, l'activité neuronale inappropriée aboutissant à des neurodysesthésies dans des maladies telles que le diabète, la sclérose en plaques et l'affection du neurone moteur, l'ataxie, la rigidité musculaire (spasticité), la dysfonction de l'articulation temporo-mandibulaire et la sclérose latérale amiotrophique.

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