C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/08 (2006.01) A61K 31/403 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2755528
The invention relates to a compound of the general formula (I), where: R is a hydrogen atom or a group selected from the (C1-C6)alkyl or (C3-C7)-cycloalkyl groups, optionally substituted by one or more groups independently selected from a halogen atom and the (C3-C7)-cycloalkyl, (C1-C6)alkyl, (C1-C6)alkoxy, and hydroxy groups; R1 is a phenyl group optionally substituted by one or more substituents independently selected from halogen atoms and the (C1- C6)alkyl, (C1-C6)alkoxy, halo-(C1C6)alkyl, hydroxy, halo-(C1-C6)alkoxy, (C1-C6)alkyl-thio, (C1-C6)alkyl-SO, and (C1-C6)alkyl-SO2 groups; R2 is one or more substituents selected from a hydrogen atom, halogen atoms, and the halo-(C1-C6)alkyl, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)-cycloalkyl-(C1C3)alkyl, phenyl, benzyl, (C1-C6)alkoxy, (C1-C6)alkyl-thio, (C1-C6))alkyl-SO, and (C1-C6)alkyl-SO2 groups; and Het is a heteroaryl group; wherein said compound is in the form of a base or an acid addition salt. The invention also relates to the therapeutic use thereof and to a method for synthesising same.
Composé de formule générale (I): dans laquelle : - R représente un atome d'hydrogène ou un groupe choisi parmi les groupes (C1-C6)alkyle ou (C3-C7)-cycloalkyle éventuellement substitué par un ou plusieurs groupes choisis indépendamment l'un de l'autre parmi l'atome d'halogène, les groupes (C3-C7)-cycloalkyle, (C1-C6)alkyle, (C1- C6)alcoxy, hydroxy; - R1 représente un groupe phényle éventuellement substitué par un ou plusieurs substituants choisis indépendamment l'un de l'autre parmi les atomes d'halogène, les groupes (C1- C6)alkyle, (C1-C6)alcoxy, halo-(C1C6)alkyle, hydroxy, halo-(C1-C6)alcoxy, (C1-C6)alkyle-thio, (C1--C6)alkyle-SO, (C1-C6)alkyle-SO2, - R2 représente un ou plusieurs substituants choisis parmi l'atome d'hydrogène, les atomes d'halogène, les groupes halo-(C1-C6)alkyle, (C1-C6)alkyle, (C3-C7)cycloalkyle, (C3-C7)- cycloalkyl-(C1C3)alkyle, phényl, benzyl, (C1-C6)alcoxy, (C1-C6)alkyle-thio, (C1-C6))alkyle-SO, (C1-C6)alkyle-SO2; - Het représente un groupe hétéroaryle; à l'état de base ou de sel d'addition à un acide. Utilisation en thérapeutique et procédé de synthèse.
Estenne-Bouhtou Genevieve
Medaisko Florence
Robic
Sanofi
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