C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
260/229.5
C07H 19/167 (2006.01) C07H 19/16 (2006.01)
Patent
CA 1305135
N-6 SUBSTITUTED ADENOSINE DERIVATIVES AS CARDIAC VASODILATORE ABSTRACT OF THE DISCLOSURE New, N-6 monosubstituted adenosine derivatives are disclosed which have significant cardiac vasodilatory effect. The compounds of the invention include 6-(cyclo-butyl amino) -9- (.beta.-D-ribofuranosyl)-9H-purine, 6-[2-methyl -2 -phenyl hydrazino]-9- (.beta.-D-ribofuranosyl) -9H- purine, and compounds of the general formula: Image wherein R1 is H, lower alkyl, lower alkoxy, alkylamino, or arylamino, R2 is H, lower alkyl, hydroxymethyl, phenyl or substituted phenyl, R3 is H, lower alkyl, phenyl, substituted phenyl, R3 is H, lower alkyl, phenyl, substituted phenyl, 2- or 3-thienyl, or 2- or 3-pyridyl, R4 is H or lower alkyl, and R5 is H or lower acyl. Particularly active as a cardiac vasodilator is the compound (-) - 6 -(R - 1 - phenyl - 2 - butyl amino) - 9 - (.beta.-D-ribofuranosyl) - 9H - purine. Compounds of the invention having a cardiovascular vasodilatory effect in mammals are prepared by a process including the step of incorporating into a pharmaceutically acceptable carrier for oral, topical or intravenous application in the proportion required for an effective dosage thereof a compound of the formulas described above.
615878
Olsson Ray A.
Thompson Robert D.
Nelson Research & Development Company
Olsson Ray A.
Rogers & Scott
Thompson Robert D.
Whitby Research Inc.
LandOfFree
N-6 substituted adenosine derivatives as cardiac vasodilators does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-6 substituted adenosine derivatives as cardiac vasodilators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-6 substituted adenosine derivatives as cardiac vasodilators will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1238145