N-acetyl-p-aminophenol composition containing partially...

Details N-acetyl-p-aminophenol composition containing partially... N-acetyl-p-aminophenol composition containing partially...

A - Human Necessities

61

K

167/269

A61K 9/20 (2006.01) A61K 31/165 (2006.01)

Patent

CA 1221308

N-ACETYL-p-AMINOPHENOL COMPOSITIONS CONTAINING PARTIALLY GELATINIZED STARCH AND METHOD FOR PREPARING SAME ABSTRACT OF THE DISCLOSURE An N-acetyl-p-aminophenol composition capable of being directly formed into a tablet having high hardness, short disintegration time and short dissolution time is disclosed. The composition includes N-acetyl-p-aminophenol, a pharmaceutically acceptable partially gelatinized starch, a pharmaceutically acceptable lubricant, water and optionally an auxiliary binder, an auxiliary disintegrant or both of these optional components. Also disclosed is a method for preparing the composition which includes forming a slurry containing the essential components (and optional components if desired) and spray drying the slurry.

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