N-acyl derivatives of amino acids, a process for preparation...

Details N-acyl derivatives of amino acids, a process for preparation... N-acyl derivatives of amino acids, a process for preparation...

C - Chemistry, Metallurgy

07

D

C07D 233/64 (2006.01) A61K 31/405 (2006.01) A61K 31/4172 (2006.01) A61P 3/06 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 37/08 (2006.01) C07D 209/20 (2006.01)

Patent

CA 2612324

The invention relates to N-acylic aminoacid derivatives of general formula (I), wherein n is 2 or 3 and R1 represents formula (II) or (III), wherein R2=H,-CH3,-C2H5 or to the pharmaceutically acceptable salts thereof, to novel methods for the production thereof in the form anti-allergic, anti- anaphylactic, anti-inflammatory and hypolipidemic agents, to a pharmacological composition containing said compounds in an effective quantity and to a method for treating allergic and inflammatory diseases and lipisoids: bronchial asthma, allergic rhinitis, pollinoses, seasonal and perennial allergic rhinitis, allergic pulmonary fever, atopic dermatitis, psoriasis, urticaria fever, insect-sting allergy (including anaphylactic) and allergic reaction to medicinal agents, cold allergy, allergic conjunctivitis, atherosclerosis, adiposis, coronary heart disease and cerebral ischemia, heart and apoplectic attacks

La présente invention concerne des dérivés N-acyles d'acides aminés possédant la formule générale suivante (I) (formule I), dans laquelle n est égal à 2 ou à 3, et dans laquelle R1 se présente comme (formule II), ou leurs sels pharmaceutiquement acceptables, leurs nouveaux procédés de fabrication, leur utilisation en tant que produits anti-allergiques, anti-anaphylactiques, anti-inflammatoires ou hypolipidémiques, ainsi qu'une composition pharmaceutique qui comprend les composés mentionnés ici dans des quantités efficaces ainsi qu'un procédé de traitement des maladies allergiques et inflammatoires et des perturbations de l'échange lipidique, de l'asthme brochial, de la rhinite allergique, des pollinoses, des rhinites saisonnières ou annuelles, de la congestion pulmonaire allergique, de la dermatite atopique, du psoriasis, de l'urticaire, des réactions allergiques (y compris anaphylactiques) aux piqûres d'insectes et aux médicaments, de l'allergie au froid, de la conjonctivite allergique, de l'athérosclérose, de l'obésité, de la maladie ischémique du coeur et du cerveau, de l'infarctus du myocarde et de l'ACV.

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