N-acyl derivatives of peptides, their preparation and their...

Details N-acyl derivatives of peptides, their preparation and their... N-acyl derivatives of peptides, their preparation and their...

C - Chemistry, Metallurgy

07

K

530/5.04, 167/10

C07K 5/04 (2006.01) C07K 5/097 (2006.01)

Patent

CA 1257748

ABSTRACT OF THE DISCLOSURE: This invention relates to new compounds of the formula: X-NH-CR2R3-CO-NH-CH2-CO-R1 (I) where R1 is an amino radical of the formula NR4R5, where R and R5 are identical or different and are each hydrogen or C1-C5-alkyl, R2 and R3 are identical or different and are each C1-C5-alkyl, phenyl, benzyl or naphtyl or, together with the carbon atom which they share, may furthermore form an aliphatic ring system of 3 to 7 carbon atoms or a 1,1- or 2,2-indanediyl radical, and X is pyrrol-2-ylcarbonyl, indol- 2-ylcarbonyl, cyclopentylcarbonyl, L-pyrrolidin-2-ylcar- bonyl, L-4,5-dehydropyrrolidin-2-ylcarbonyl, L-5-oxopyrro- lidin-2-ylcarbonyl, L-1,3-thiazolidin-4-ylcarbonyl or L-1,4- thiazan-2-ylcarbonyl, and its salts with physiologically tolerated acids. These new compounds are useful for treating disorders, especially Parkinson's disease, Parkinson's like conditions and depressions.

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