N-acyl-n-naphthoylglycines as aldose reductase inhibitors

Details N-acyl-n-naphthoylglycines as aldose reductase inhibitors N-acyl-n-naphthoylglycines as aldose reductase inhibitors

C - Chemistry, Metallurgy

07

C

167/249, 260/468

C07C 271/64 (2006.01) A61K 31/27 (2006.01) C07C 43/225 (2006.01) C07C 235/66 (2006.01)

Patent

CA 1326680

ABSTRACT OF THE DISCLOSURE Disclosed herein are N-acyl-N-naphthoylglycines and methods of their preparation. The N-acyl-N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications. The N-acyl-N-naphthoylglycines have the following formula Image (I) wherein R1 is halogen or lower perfluoroalkoxy containing 1 to 3 carbon atoms; R2 is lower alkyl preferably containing 1 to 3 carbon atoms; X is -OH or -NH2, and the pharmaceutically acceptable salts thereof, wherein X is -OH.

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