N-acyl-polypeptides and processes for the production thereof

Details N-acyl-polypeptides and processes for the production thereof N-acyl-polypeptides and processes for the production thereof

C - Chemistry, Metallurgy

07

K

530/7.02, 530/7.

C07K 14/655 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1188682

- 1 - Abstract: N-Acyl-polypeptides comprising the basic sequence Image wherein "Acyl" is the acyl residue of an organic or inorganic acid; A is H or alkyl; >N-CH(Z)-CO- and E are the residues of natural .alpha.-amino acids or corresponding (D)-amino acids; C is -Trp- or -(D)Trp-; F is a terminal grouping; and Y1 and Y2 are each H or together are a direct bond; as well as their salt forms and complexes. They can be used in the treatment of disorders with an aetiology associated with excess G-H-secretion, treatment of gastro-intestinal disorders, etc.

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