C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/104.1
C07D 501/24 (2006.01) A61K 31/545 (2006.01) C07D 501/04 (2006.01) C07D 501/20 (2006.01) C07D 501/26 (2006.01) C07D 501/32 (2006.01) C07D 501/34 (2006.01) C07D 501/36 (2006.01) C07D 501/44 (2006.01) C07D 501/46 (2006.01) C07D 501/54 (2006.01) C07D 501/56 (2006.01) C07D 501/60 (2006.01) C07D 519/00 (2006.01)
Patent
CA 1074784
S-1-14918C/75 (F-13883) ABSTRACT OF THE DISCLOSURE A cephalosporin derivative of the formula (I), Image wherein A is a mono- or polycyclic heteroaromatic ring, which contains at least one nitrogen atom as a hetero atom and which may be substituted with one or more substituents; R is a phenyl group substituted with at least one substituent selected from the group consisting of an amino group, a hydroxy group, a ureido group and a hydroxymethyl group; and X is an -OCOCH3 group or an -S-Het group in which Het is a 5- or 6-membered hetero- cyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms which may be substituted with one or more substituents, and the non- toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial and prepared by the reaction of a compound of the formula (II), HO-A-COOH (II) wherein A is as defined above, or a reactive derivative thereof, with a compound of the formula (III), Image wherein R and X are as defined above, or a derivative thereof.
234729
Eda Yasuko
Irie Kenji
Izawa Akio
Komatsu Toshiaki
Nakagome Takenari
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