N-acylaminoalkylhydrazinecarboximidamides

Details N-acylaminoalkylhydrazinecarboximidamides N-acylaminoalkylhydrazinecarboximidamides

C - Chemistry, Metallurgy

07

C

C07C 281/16 (2006.01) A61K 31/155 (2006.01)

Patent

CA 2241746

The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) using compounds of formula (I), wherein alk is a straight or branched chain alkylene group containing from 2 to 8 carbon atoms, and R is a lower alkyl group containing from 1 to 6 carbon atoms; and their biologically or pharmaceutically acceptable acid addition salts. Accordingly, a composition is disclosed which comprises these N- acylaminoalkylhydrazinecarboximidamides, which are capable of inhibiting the formation of advanced glycosylation endproducts of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

Compositions et procédés permettant d'inhiber la réticulation non enzymatique (le vieillissement des protéines) à l'aide de composés de formule (I). Dans cette formule alk représente un groupe alkylène à chaîne linéaire ou ramifiée contenant de 2 à 8 atomes de carbone et R représente un groupe alkyle inférieur contenant de 1 à 6 atomes de carbone; ainsi que leurs sels d'addition acide biologiquement ou pharmaceutiquement acceptables. On décrit donc une composition qui contient ces N-acylaminoalkylhydrazinecarboximidamides et permet d'inhiber la formation de produits terminaux de glycosylation avancée de protéines cibles. Le procédé consiste à mettre en contact la protéine cible avec la composition. Des applications aussi bien industrielles que thérapeutiques sont envisagées pour cette invention, cette dernière permettant de traiter le vieillissement protéinique des animaux et d'empêcher la détérioration des denrées alimentaires.

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