N-acylated lipophilic amino acid derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 281/16 (2006.01) A61K 31/55 (2006.01) A61K 31/553 (2006.01) A61K 31/554 (2006.01) C07D 223/16 (2006.01) C07D 267/14 (2006.01) C07D 267/16 (2006.01) C07D 281/10 (2006.01) A61K 31/663 (2006.01) A61K 38/25 (2006.01)

Patent

CA 2301566

Disclosed are the novel compounds represented by structural Formula (I), wherein A is a lipophilic group comprising an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.

La présente invention concerne des composés représentés par la formule générale (I). A est ici un groupe lipophile comprenant un groupe passerelle aliphatique. B est un groupe lipophile. D est un groupe comportant au moins un groupe amino ou un groupe amino substitué. R est hydrogène, alkyle ou cycloalkyle. L'invention concerne également des sels pharmaceutiquement admis de ces composés, certains de leurs isomères pris un à un. Ces produits présentent une activité de libération d'hormone de croissance chez l'homme et les autres animaux.

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