C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/192 (2006.01) A61K 31/495 (2006.01) C07D 213/56 (2006.01) C07D 213/79 (2006.01) C07D 213/80 (2006.01) C07D 317/60 (2006.01) C07D 317/68 (2006.01)
Patent
CA 2216763
An N-acylpiperazine derivative or a salt thereof expressed by the following formula 1: (see fig. I) wherein R1 represents a pyridylcarbonyloxy lower alkyl group, a benzoylamino lower alkyl group, benzyl group, carbamoyl group, pyridyl group, or diphenylmethyl group; R2 represents a lower alkyl group or a lower alkoxy group; n represents an integer of 0 to 2; R3 represents a hydrogen atom, an alkenyl group, or benzyl group; and m represents an integer of 1 to 3. The N-acylpiperazine derivative or a salt thereof has an anti-ulcer effect, an antibacterial activity against Helicobacter pyroli, and high safety to be available for prevention or cure of various ulcers.
Dérivé de N-acylpipérazine ou un de ses sels, de formule 1 (voir fig. I), où R1 représente un groupe pyridylcarbonyloxy-alkyle inférieur, benzoylamino-alkyle inférieur, benzyle, carbamoyle, pyridyle ou diphénylméthyle; R2 représente un alkyle inférieur ou un alcoxy inférieur; n est un entier de 0 à 2; R3 est un atome d'hydrogène, un alcényle ou un benzyle; m est un entier de 1 à 3. Le dérivé de N-acylpipérazine ou l'un de ses sels ont un effet anti-ulcères et une activité antibactérienne contre Helicobacter pyroli; il est très sûr pour la prévention ou le traitement de divers ulcères.
Fukunishi Hirotada
Nishino Chikao
Sato Fumitaka
Gowling Lafleur Henderson Llp
Shiseido Co. Ltd.
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