N-acylsulfonamide apoptosis promoters

Details N-acylsulfonamide apoptosis promoters N-acylsulfonamide apoptosis promoters

C - Chemistry, Metallurgy

07

C

C07C 311/51 (2006.01) A61K 31/18 (2006.01) A61P 35/00 (2006.01) C07C 317/28 (2006.01) C07C 323/12 (2006.01) C07C 323/17 (2006.01) C07C 323/25 (2006.01) C07C 323/30 (2006.01) C07C 323/37 (2006.01) C07C 323/58 (2006.01) C07C 323/60 (2006.01) C07D 203/10 (2006.01) C07D 205/12 (2006.01) C07D 207/24 (2006.01) C07D 207/404 (2006.01) C07D 209/08 (2006.01) C07D 209/96 (2006.01) C07D 211/44 (2006.01) C07D 211/70 (2006.01) C07D 211/74 (2006.01) C07D 213/61 (2006.01) C07D 213/70 (2006.01) C07D 213/71 (2006.01) C07D 21

Patent

CA 2423103

N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

Cette invention se rapporte à des N-benzoyl-arylsulfonamides, représentés par la formule (I), qui sont des inhibiteurs de BCL-X1 et servent à promouvoir l'apoptose. Cette invention concerne également des compositions inhibant la protéine BCL-X1 et des procédés destinés à promouvoir l'apoptose chez un mammifère.

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