N-acylthiourea and n-acylurea inhibitors of the hedgehog...

C - Chemistry – Metallurgy – 07 – C

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Details

C07C 335/26 (2006.01) A61K 31/155 (2006.01) A61K 31/17 (2006.01) A61K 31/341 (2006.01) A61K 31/357 (2006.01) A61K 31/381 (2006.01) A61K 31/4409 (2006.01) A61P 3/10 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07C 275/40 (2006.01) C07C 275/54 (2006.01) C07C 335/24 (2006.01) C07D 209/06 (2006.01) C07D 213/81 (2006.01) C07D 235/14 (2006.01) C07D 307/68 (2006.01) C07D 317/68 (2006.01) C07D 319/18 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2722258

The present invention relates to the use of acylthiourea or acylurea derivatives of formula (I) for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel acylthiourea or acylurea derivatives of formula (I) as such, to their use as a medicinal product, and to pharmaceutical compositions containing them.

La présente invention est relative à l'utilisation de dérivés d'acyl-thiourées ou d'acyl-urées de la formule (I) pour le traitement de pathologies impliquant un dysfonctionnement tissulaire lié à une dérégulation de la voie de signalisation des protéines Hedgehog, ainsi qu'à de nouveaux dérivés d'acyl-thiourées ou d'acyl- urées de la formule (I) en tant que tels, à leur utilisation comme médicament, et aux compositions pharmaceutiques les contenant. Formule (I)

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