N-alkanoylphenylalanine derivatives

Details N-alkanoylphenylalanine derivatives N-alkanoylphenylalanine derivatives

C - Chemistry, Metallurgy

07

C

C07C 237/24 (2006.01) A61K 31/198 (2006.01) A61K 31/4166 (2006.01) A61K 31/4178 (2006.01) A61K 31/47 (2006.01) C07D 215/50 (2006.01) C07D 233/38 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2300121

Compounds of formula (I) are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and /or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

La présente invention concerne des composés de la formule (I) présentant une activité d'inhibiteurs de la liaison entre la VCAM-1 et les cellules exprimant la VLA-4. Ces composés sont utilisés pour traiter les maladies dont les symptômes et/ou les lésions sont associées à la liaison de la VCAM-1 avec les cellules exprimant la VLA-4.

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