N-alkyl derivatives of 1-phenyl-2-amino-1, 3-propandiol and...

Details N-alkyl derivatives of 1-phenyl-2-amino-1, 3-propandiol and... N-alkyl derivatives of 1-phenyl-2-amino-1, 3-propandiol and...

B - Operations, Transporting

01

J

260/604.1, 260/6

B01J 25/00 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) B01J 23/40 (2006.01)

Patent

CA 1131252

ABSTRACT OF THE DISCLOSURE The invention relates to novel 1-phenyl-2-amino-1,3- propanediol-N-alkyl derivatives having the general formula I (I) Image wherein R1 is hydrogen, alkyl having from 1 to 8 carbon atoms or phenoxymethyl, and R2 is hydrogen, alkyl having from 1 to 8 carbon atoms or 2,2-diphenylethyl, with the proviso that if R1 is phenoxymethyl then R2 may stand only for methyl, and if R2 2,2-diphenylethyl then R1 may stand only for hydrogen, and its isomer and pharmaceutically acceptable salts. Furthermore, the invention relates to a process for preparing these compounds. The novel 1-phenyl-2-amino-1,3-propanediol-N-alkyl derivatives having the general formula I possess significant anti-anginose activity and show several other biological activities.

298640

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