N-alkylated 1,4-dihydropyridinedicarboxylic acid esters

Details N-alkylated 1,4-dihydropyridinedicarboxylic acid esters N-alkylated 1,4-dihydropyridinedicarboxylic acid esters

C - Chemistry, Metallurgy

07

D

C07D 211/90 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2074777

ABSTRACT N-alkylated 1,4-dihydropyridinedicarboxylic acid esters of the formula: Image (I) (wherein R1 is OCF3, CN, F, Cl or CF3, and R2 is CH3, C2H5 or Image , with the proviso that R1 is not CF3 when R2 is CH3) are prepared either by reaction of aldehydes with acetoacetic esters and amines, optionally with isolation of the corresponding ylidene compounds, or by reaction of aminocrotonic acid esters with ylidene compounds and subsequent alkylation of the NH function. The N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be employed as active compounds in medicaments, in particular as cerebral therapeutics.

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