N-alkylated aminoalcohols and their salts, processes for...

Details N-alkylated aminoalcohols and their salts, processes for... N-alkylated aminoalcohols and their salts, processes for...

C - Chemistry, Metallurgy

07

D

260/296, 260/297

C07D 307/54 (2006.01) C07C 229/38 (2006.01) C07D 213/38 (2006.01) C07D 213/56 (2006.01) C07D 265/22 (2006.01) C07D 307/52 (2006.01) C07D 333/20 (2006.01)

Patent

CA 1124241

ABSTRACT OF tHE DISCLOSURE The invention relates to novel N-alkylated aminoalcohols of the formula Image (I) in which Ar denotes phenyl unsubstituted or substituted by one or two hydroxyl groups, pyridyl, furyl or thienyl, n has the values nought or 1 and Alk is an alkylene radieal having 2 to 5 carbon atoms and the nitrogen and the oxygen atom, or, if n is nought, the phenyl radical are separated from one another by at least 2 carbon atoms, in the form of mixtures of racemates, stereomeric (diastereomeric) racemates, optical antipodes or pharmaceutically acceptable non-toxic acid addition salts and processes for their preparation. The main action of the novel compounds consists in a stimulation of cardiac .alpha.-raceptors; the oompounds also effect a blockage of adrenergic .alpha.-reeeptors and a lowering in the blood pressure. They can therefore be used as .beta.-stimulators, especially as agents having a positively inotropic action for the treatment of cardiac insuffieiency.

328929

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