N-alkylthio polyamine derivatives as radioprotective agents

Details N-alkylthio polyamine derivatives as radioprotective agents N-alkylthio polyamine derivatives as radioprotective agents

C - Chemistry, Metallurgy

07

C

C07C 323/25 (2006.01) A61K 31/13 (2006.01) A61K 31/66 (2006.01) C07C 323/67 (2006.01) C07F 9/165 (2006.01)

Patent

CA 2161869

The present invention relates to certain polyamine thiols which are useful as radioprotective agents and which have the following formula (I) or (II) (see formula I) wherein m is an integer from 2 to 4, n is an integer from 4 to 10, R is C2-C6 alkyl, and B1, B2, B3 and B4 are each independently H, -CH2CH2SH or -CH2CH2SPO3H2; with the proviso that at least one of B1, B2, B3 or B4 is other than H; or (see formula II) wherein m is an integer from 2 to 4, n is an integer from 3 to 10, R is C2-C6 alkyl, and B1, B2 and B3 are each independently H, -CH2CH2SH or -CH2CH2SPO3H2; with the proviso that at least one of B1, B2 or B3, is other than H; and the pharmaceutically acceptable addition salts thereof.

L'invention se rapporte à certains polyamine thiols utilisés comme agents radioprotecteurs.

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