N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as...

Details N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as... N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as...

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/395 (2006.01) A61K 31/4545 (2006.01) A61K 31/497 (2006.01) A61K 31/505 (2006.01) A61P 3/10 (2006.01) C07D 207/16 (2006.01) C07D 211/58 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 451/04 (2006.01) C07D 451/14 (2006.01)

Patent

CA 2475312

The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms. Specifically, the invention relates to compounds of the general formula (I) (see formula I) - wherein R1 means a nitrogen-containing aromatic moiety consisting of one or two aromatic rings, which is, optionally mono- or disubstituted by one or two of the following groups: C1-4 alkyl groups, C1-4 alkoxy groups, halogen atom, trihalogenomethyl group, methylthio group, nitro group, cyano group, amino group or phenyl group; etc B stands for - a group of formula (1) or (2) or (3) or (4) or (5) or (6) or (7); (see formula 1), etc R2 stands for hydrogen atom or fluorine atom; R3 stands for fluorine atom; and salts, tautomers, solvates and hydrates thereof.

la présente invention concerne des nouveaux et puissants inhibiteurs d'enzyme DPP-IV, représentés par la formule (I), qui renferment des atomes de fluor.

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