N-aminobutyl-n-phenylarylamide derivatives, their...

Details N-aminobutyl-n-phenylarylamide derivatives, their... N-aminobutyl-n-phenylarylamide derivatives, their...

C - Chemistry, Metallurgy

07

C

167/268, 260/292

C07C 233/75 (2006.01) A61K 31/165 (2006.01) C07D 211/14 (2006.01) C07D 213/74 (2006.01) C07D 213/82 (2006.01) C07D 215/50 (2006.01) C07D 217/04 (2006.01) C07D 217/26 (2006.01) C07D 295/13 (2006.01) C07D 295/145 (2006.01)

Patent

CA 1306748

Abstract compound of formula (I) (I) Image in which: X denotes hydrogen, a halogen, a trifluoromethyl group, a C1-C6 alkyl group or a C1-C4 alkoxy group; R1 denotes a linear or branched C2-C8 alkyl group, a C3-C5 cycloalkyl group or a cycloalkylmethyl group in which the cycloalkyl moiety has from 3 to 5 carbon atoms; R2 denotes hydrogen or a C1-C4 alkyl group; R3 denotes hydrogen, a C1-C4 alkyl group, an optionally substituted phenylalkyl group or a pyridylalkyl group; or R2 and R3 denote, together with the nitrogen to which they are attached, a pyrrolidinyl, piperidyl, morpholinyl, perhydrothiazinyl, piperazinyl or 4-methylpiperazinyl ring; and Ar denotes a phenyl group, optionally having from one to three substituents, each of which is, independently, a halogen or a C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl, nitro or cyano group, or Ar denotes a naphthyl, pyridyl, quinolinyl or isoquinolinyl group; or a pharmacologically acceptable acid addition salt thereof. The compounds are calcium antagonists.

572175

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