C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61P 3/10 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) A61P 15/00 (2006.01) A61P 17/00 (2006.01) A61P 25/04 (2006.01) A61P 25/24 (2006.01) A61P 29/00 (2006.01) C07D 213/74 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2658799
The invention concerns compounds of general formula (I) : wherein Z1, Z2, Z3, and Z4 represent, independently of one another, a nitrogen atom or a C(R6) group, at least one of which corresponds to a nitrogen atom and at least one of which corresponds to a C(R6) group, n is equal to 0, 1, 2 or 3, Y represents an optionally substituted aryl or heteroaryl, and Z represents a cyclic amine bound by the nitrogen atom of formula , in the base or acid addition salt state, and in the hydrate or solvate state. The invention also concerns a preparation method and a therapeutic application.
L'invention concerne des composés de formule générale (I) : dans laquelle Z1, Z2 , Z3, Z4 représentent, indépendamment l'un de l'autre, un atome d'azote ou un groupe C(R6), l'un au moins correspondant à un atome d'azote et l'un au moins correspondant à un groupe C(R6); n est égal à 0, 1, 2 ou 3; Y représente un aryle ou un hétéroaryle éventuellement substitué; Z représente une aminé cyclique reliée par l'atome d'azote, de formule :; à l'état de base ou de sel d'addition à un acide, ainsi qu'à l'état d'hydrate ou de solvat. Procédé de préparation et application en thérapeutique.
Dubois Laurent
Evanno Yannick
Gille Catherine
Machnik David
Malanda Andre
Robic
Sanofi-Aventis
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