N-aroylphenylalanine derivatives

Details N-aroylphenylalanine derivatives N-aroylphenylalanine derivatives

C - Chemistry, Metallurgy

07

C

C07C 233/87 (2006.01) A61K 31/165 (2006.01) A61K 31/395 (2006.01) C07C 235/52 (2006.01) C07C 237/36 (2006.01) C07C 311/17 (2006.01) C07C 311/21 (2006.01) C07C 317/44 (2006.01) C07C 317/50 (2006.01) C07C 323/39 (2006.01) C07C 323/62 (2006.01) C07D 211/64 (2006.01) C07D 213/82 (2006.01) C07D 215/30 (2006.01) C07D 215/50 (2006.01) C07D 233/32 (2006.01) C07D 233/36 (2006.01) C07D 239/28 (2006.01) C07D 249/06 (2006.01) C07D 261/18 (2006.01) C07D 277/56 (2006.01) C07D 295/088 (2006.01) C07D 295/15 (2006.01) C07D

Patent

CA 2301377

Compounds of formula (1) as well as their salts and esters are disclosed wherein X, X', Z and Y are as described in the specification and which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

La présente invention concerne des composés représentés par la formule générale (1), ainsi que leurs sels et esters. En l'occurrence, X, X', Z et Y, qui sont conformes aux descriptions des spécifications de la présente demande, présentent une activité d'inhibition de la liaison entre le VCAM-1 et les cellules à expression de VLA-4. De tels composés conviennent pour le traitement d'affections dont les symptômes et/ou les atteintes sont en relation avec la liaison entre VCAM-1 et les cellules à expression de VLA-4.

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