C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 255/58 (2006.01) A61K 31/13 (2006.01) A61K 31/275 (2006.01) A61K 31/435 (2006.01) A61K 31/445 (2006.01) A61K 31/505 (2006.01) C07C 225/20 (2006.01) C07C 233/41 (2006.01) C07C 311/12 (2006.01) C07C 317/32 (2006.01) C07D 213/72 (2006.01) C07D 213/78 (2006.01) C07D 215/38 (2006.01) C07D 217/22 (2006.01) C07D 231/56 (2006.01) C07D 233/61 (2006.01) C07D 235/08 (2006.01) C07D 239/28 (2006.01)
Patent
CA 2204415
The compounds of formula (I), wherein R1 is hydrogen, C1-10 straight or branched chain alkyl, C3-10 cyclic or bicyclic alkyl, alkanoyl of 2 to 7 carbon atoms, alkylsulfonyl of 1 to 7 carbon atoms, aroyl of 7 to 12 carbon atoms, arylalkenoyl of 9 to 20 carbon atoms, arylsulfonyl of 6 to 12 carbon atoms, arylalkanoyl of 8 to 12 carbon atoms or arylalkylsulfonyl of 7 to 12 carbon atoms; R2 is hydrogen, C1-10 straight or branched chain alkyl or C3-10 cyclic or bicyclic alkyl; A is a group of formula (II), wherein R7 and R8, independent from each other, are selected from the following: cyano, nitro, amino, C1-6 alkyl, C1-6 perfluoroalkyl, C1-6 alkoxy, C1-6 perfluoroalkoxy, amino, C1-12 mono- or dialkylamino, sulfonamide, C1-6 alkylsulfonamido, C6-12 arylsulfonamido, C2-6 alkylcarboxamido, C7-12 arylcarboxamido, C1-6 alkylsulfonyl, C1-6 perfluoroalkylsulfonyl, C6-12 arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl, carboxyl, carboalkoxy of 2 to 7 carbon atoms, hydroxyl or hydrogen; or A is Het where Het is selected from (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o), (p), wherein R9 is hydrogen, C1-6 alkyl, C1-6 perfluoroalkyl, C1-6 alkoxy, C1-6 perfluoroalkoxy, amino, C1-12 mono- or dialkylamino, C1-6 alkylsulfonamido, C2-6 alkylcarboxamido, nitro, cyano, carboxyl, chloro, bromo, fluoro, iodo; n is an integer from 0 to 6; R3 and R4 are, independent from each other, hydrogen, C1- 10 straight or branched chain alkyl, or C3-10 cyclic or bicyclic alkyl; C1-10 perfluoro alkyl, C1-10 hydroxyalkyl, C2-10 alkoxyalkyl, fluoro; or, when taken together, form a spirocyclic ring containing a total of 3-7 carbon atoms; R5 and R6, independent from each other, are selected from the following: cyano, nitro, amino, C1-6 alkyl, C1-6 perfluoroalkyl, C1-6 alkoxy, C1-6 perfluoroalkoxy, amino, C1-12 mono- or dialkylamino, sulfonamide, C1-6 alkylsulfonamido, C6-12 arylsulfonamido, C2-6 alkylcarboxamido, C7-12 arylcarboxamido, C1-6 alkylsulfonyl, C1-6 perfluoroalkylsulfonyl, C6-12 arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl, carboxyl, C2-7 carboalkoxy, hydroxyl, or hydrogen; or a pharmaceutically acceptable salt thereof.
L'invention concerne les composés de la formule (I). Dans cette formule, R¿1? est un hydrogène, un C¿1-10? alkyle à chaîne droite ou ramifiée, un C¿3?-¿10? alkyle cyclique ou bicyclique, un alcanoyle à 2-7 atomes de carbone, un alkylsulfonyle à 1-7 atomes de carbone, un aroyle à 7-12 atomes de carbone, un arylalcénoyle à 9-20 atomes de carbone, un arylsulfonyle à 6-12 atomes de carbone, un arylalcanoyle à 8-12 atomes de carbone ou un arylalkylsulfonyle à 7-12 atomes de carbone; R¿2? est un hydrogène, un C¿1-10? alkyle à chaîne droite ou ramifiée ou un C¿3-10? alkyle cyclique ou bicyclique; A est un groupe de la formule (II). Dans cette formule, R¿7? et R¿8? sont choisis d'une manière indépendante parmi les groupes cyano, nitro, amino, C¿1-6? alkyle, C¿1-6? perfluoroalkyle, C¿1-6? alcoxy, C¿1-6? perfluoroalcoxy, amino, C¿1-12? mono- ou dialkylamino, sulfonamide, C¿1-6? alkylsulfonamido, C¿6-12? arylsulfonamido, C¿2-6? alkylcarboxamido, C¿7-12? arylcarboxyamido, C¿1-6? alkylsulfonyle, C¿1-6? perfluoroalkylsulfonyle, C¿6-12? arylsulfonyle, chloro, bromo, fluoro, iodo, 1-imidazolyle, carboxyle, carboalcoxy à 2-7 atomes de carbone, hydroxyle ou hydrogène. A peut également être un groupe Het choisi parmi les groupes de formules (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o), (p). Dans ces formules, R¿9? est un hydrogène, un C¿1-6? alkyle, un C¿1-6? perfluoroalkyle, un C¿1-6? alcoxy, un C¿1-6? perfluoroalcoxy, un amino, un C¿1-12? mono- ou dialkylamino, un C¿1-6? alkylsulfonamido, un C¿2-6? alkylcarboxyamido, un nitro, un cyano, un carboxyle, un chloro, un bromo, un fluoro ou un iodo; n est un nombre entier entre 0 et 6; R¿3? et R¿4? sont d'une manière indépendante un hydrogène, un C¿1-10? alkyle à chaîne droite ou ramifiée, ou un C¿3-10? alkyle cyclique ou bicyclique; un C¿1-10? perfluoroalkyle, un C¿1-10? hydroxyalkyle, un C¿2-10? alcoxyalkyle, un fluoro ou, pris, ensemble, ils forment un groupe spirocyclique contenant en tout 3-7 atomes de carbone; R¿5? et R¿6? sont choisis d'une manière indépendante parmi les groupes suivants: cyano, nitro, amino, C¿1-6? alkyle, C¿1-6? perfluoroalkyle, C¿1-6? alcoxy, C¿1-6? perfluoroalcoxy, amino, C¿1-12? mono- ou dialkylamino, sulfonamide, C¿1-6? alkylsulfonamido, C¿6-12? arylsulfonamido, C¿2-6? alkylcarboxamido, C¿7-12? arylcarboxamido, C¿1-6? alkylsulfonyle, C¿1-6? perfluoroalkylsulfonyle, C¿6-12? arylsulfonyle, chloro, bromo, fluoro, iodo, 1-imidazolyle, carboxyle, C¿2-7? carboalcoxy, hydroxyle ou hydrogène. L'invention concerne également les sels de ces composés acceptables sur le plan pharmaceutique.
Antane Schuyler Adam
Butera John Anthony
Hirth Bradford Hammond
American Home Products Corporation
Ridout & Maybee Llp
LandOfFree
N-aryl and n-heteroaryl-1,2-diaminocyclobutene-3,4-diones... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-aryl and n-heteroaryl-1,2-diaminocyclobutene-3,4-diones..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-aryl and n-heteroaryl-1,2-diaminocyclobutene-3,4-diones... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1642818