N-aryl-(homopiperazinyl)-cyclohexyl amines as 5-ht transporters

Details N-aryl-(homopiperazinyl)-cyclohexyl amines as 5-ht transporters N-aryl-(homopiperazinyl)-cyclohexyl amines as 5-ht transporters

C - Chemistry, Metallurgy

07

D

C07D 403/08 (2006.01) A61K 31/551 (2006.01) A61P 43/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2390530

This invention provides novel compounds and methods and compositions using them in the treatment of central nervous system disorders, including depression and anxiety, the compounds having the formula (I) wherein Ar is an aryl, arylalkyl or a heteroaryl group; R1 and R2 are independently selected from hydrogen, alkyl of 1 to 12 carbon atoms which may be substituted or cycloalkyl of 3 to 10 carbon atoms which may be substituted; R3 is H, alkyl which may be substituted, cyclic alkyl which may be substituted, halogen, alkoxy, haloalkyl, OH, nitro, amino, CN, carboxy, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl and alkylaminocarbonyl; or a pharmaceutically acceptable salt thereof.

Cette invention se rapporte à de nouveaux composés et à de nouveaux procédés, ainsi qu'à des compositions utilisant ces composés et ces procédés dans le traitement des troubles du système nerveux central, tels que la dépression et l'anxiété, ces composés étant représentés par la formule (I), où Ar représente un aryle, un arylalkyle ou un groupe hétéroaryle; R¿1? et R¿2? sont choisis séparément parmi hydrogène, alkyle de 1 à 12 atomes de carbone pouvant être substitué ou cycloalkyle de 3 à 10 atomes de carbone pouvant être substitué; R¿3? représente H, alkyle pouvant être substitué, alkyle cyclique pouvant être substitué, halogène, alcoxy, haloalkyle, OH, nitro, amino, CN, carboxy, alcoxycarbonyle, alkylcarbonyle, aminocarbonyle et alkylaminocarbonyle; et à un sel de ces composés acceptable sur le plan pharmaceutique.

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