N-aryl-n'-arylcycloalkyl-urea derivatives as mch antagonists...

Details N-aryl-n'-arylcycloalkyl-urea derivatives as mch antagonists... N-aryl-n'-arylcycloalkyl-urea derivatives as mch antagonists...

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/17 (2006.01) A61K 31/275 (2006.01) A61K 31/381 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/5375 (2006.01) A61P 3/04 (2006.01) C07C 275/30 (2006.01) C07C 275/40 (2006.01) C07D 205/04 (2006.01) C07D 207/06 (2006.01) C07D 207/08 (2006.01) C07D 207/10 (2006.01) C07D 207/12 (2006.01) C07D 207/14 (2006.01) C07D 209/52 (2006.01) C07D 211/26 (2006.01) C07D 211/34 (2006.01) C07D 211/96 (2006.01) C07D 213/7

Patent

CA 2468967

The present invention discloses compounds of the formula I which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

L'invention porte sur des composés de formule (I), nouveaux antagonistes de l'hormone de concentration de la mélanine (MCH), et sur leur procédé de préparation. L'invention porte également sur des préparations pharmaceutiques comprenant lesdits antagonistes et leurs procédés d'utilisation pour traiter l'obésité, les troubles du métabolisme, les troubles de l'alimentation tels que l'hyperphagie, et le diabète.

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