C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/68 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/506 (2006.01) A61P 31/18 (2006.01) C07D 333/38 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2384134
Compounds of formula (I) wherein A and X are independently oxygen or sulphur; R6 is H, halogen, alkyl, akoxy, alkylthio, cyano, or nitro; Y is -CH2O-, -OCH2- , -CH2S-, or -CH2SO2-; Q is a substituted or unsubstituted phenyl or aromatic heterocylic group; useful for the inhibition of the replication of HIV-1, in vitro and in vivo.
L'invention concerne des composés de la formule (I). A et X représentent indépendamment oxygène et soufre; R?6¿ représente hydrogène, halogène, alkyle, alcoxy, alkylthio, cyano ou nitro; Y représente -CH¿2?O-, -OCH¿2?, -CH¿2?S- ou -CH¿2?SO¿2?-; Q est un phényle substitué ou non substitué ou un groupe hétérocyclique aromatique. Lesdits composés sont utiles pour inhiber la réplication du VIH-1, in vitro et in vivo.
Brouwer Walter Gerhard
Osika Ewa Maria
Chemtura Canada Co./cie
Chemtura Corporation
Crompton Co./cie
Gowling Lafleur Henderson Llp
Uniroyal Chemical Company Inc.
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