N-aryloxy(thio)alkyl-azacycloalkanes useful as calcium...

Details N-aryloxy(thio)alkyl-azacycloalkanes useful as calcium... N-aryloxy(thio)alkyl-azacycloalkanes useful as calcium...

C - Chemistry, Metallurgy

07

D

C07D 295/088 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01) C07D 207/08 (2006.01) C07D 211/14 (2006.01) C07D 211/46 (2006.01) C07D 295/092 (2006.01) C07D 307/91 (2006.01) C07D 317/64 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2133984

2133984 9322302 PCTABScor01 Use of compounds of formula (I), in which n is 3 to 8; q is 5 to 11; R1 represents C1-6alkyl or C1-6alkoxy; s is zero, 1 or 2; X represents oxygen or sulphur; and Ar represents phenyl optionally substituted by 1-3 substituents selected from halo, C1-8alkyl, C1-8alkoxy, C1-2alkylenedioxy, trifluoromethyl, trifluoromethyloxy, or a group Ph-(CH2)m-Y-(CH2)p-where Ph is optionally substituted phenyl, m and p are independently 0 to 4 and Y is a bond, O, S, or CH=CH, provided that m + p is not greater than 4, or Ar is an optionally substituted tricyclic heteroaryl group (a) in which Y1 is Y(CH2)x where x is 0 or 1 and Y is O, S or NR where R is hydrogen or C1-4alkyl, Z is (CH2)r or -CH=CH-, r is 0, 1 or 2 or Ar is the corresponding tricyclic dehydro ring system, and their pharmaceutically acceptable salts for the manufacture of medicaments for the treatment of conditions where a calcium channel antagonist is indicated. Novel compounds of formula (I), processes for preparing them and pharmaceutical compositions containing them are also described.

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