N-(aryloxyalkyl)heteroaryl-8-azabicyclo¬3.2.1|octanes,...

C - Chemistry – Metallurgy – 07 – D

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C07D 451/02 (2006.01) A61K 31/46 (2006.01)

Patent

CA 2060573

This invention relates to compounds of the formula (See formula I) where X is -O-, -S- or -NH-: Y is hydrogen, halogen and loweralkoxy; p is 1 or 2: n is 2, 3 or 4; R is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, amino, loweralkylamino, nitro, loweralkylthio, trifluoromethoxy, cyano, trifluoromethyl,(See formula II)alkyl or (See formula III)aryl where aryl is (See formula IV); R1 is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, carboxyl, loweralkylamino, nitro, loweralkylthio, cyano, and trifluoromethyl; m is 1 or 2; a pharmaceutically acceptable acid addition salt thereof and, where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds and compositions of this invention are useful as antipsychotic agents and as inhibitors of the reuptake of serotonin.

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