N-arylsulfonyl-3-aminoalkoxyindoles

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 209/36 (2006.01) A61K 31/429 (2006.01) C07D 209/00 (2006.01)

Patent

CA 2507505

The present invention describes substituted 3-Aminoalkoxyindoles, compounds of the general formula (I), its stereoisomers, its radioisotopes, its geometric forms, its N-oxides, its polymorphs, its pharmaceutically acceptable salts, its pharmaceutically acceptable solvates, its useful bio-active metabolites and any suitable combination of the above. The invention also discloses the processes for preparing such compounds of the general formula (I), its stereoisomers, its radioisotopes, its geometric forms, its N-oxides, its polymorphs, its pharmaceutically acceptable salts, its pharmaceutically acceptable solvates, its useful bio-active metabolites and also includes any suitable combination of the above. Further described are various methods of administering these compounds of general formula (I), i.e. pharmaceutically acceptable dosage forms, their composition and their use in either therapy or diagnosis.

L'invention concerne des 3-aminoalkoxyindoles substitués, les composés représentés par la formule générale (I), et les stéréo-isomères, les radio-isotopes, les formes géométriques, les N-oxydes, les polymorphes, les sels pharmaceutiquement acceptables, les solvates pharmaceutiquement acceptables, et les métabolites bio-actifs de ces composés, ainsi qu'une combinaison adéquate quelconque des précédents. L'invention concerne également des procédés permettant de préparer ces composés de formule générale (I), et les stéréo-isomères, les radio-isotopes, les formes géométriques, les N-oxydes, les polymorphes, les sels pharmaceutiquement acceptables, les solvates pharmaceutiquement acceptables, et les métabolites bio-actifs de ces composés, ou une combinaison adéquate quelconque des précédents. L'invention concerne en outre divers modes d'administration de ces composés de formule générale (I), ou diverses formes posologiques pharmaceutiquement acceptables, ainsi que les compositions et les utilisations de celles-ci à des fins de traitement ou de diagnostic.

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